hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression

High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively CRC patient survival. Previous studies have revealed that hTERT can reduce cancer cellular reactive oxygen species (ROS) levels accelerate progression; however, the mechanism remains poorly understood. NFE2-related factor 2 (NRF2) a molecule plays significant role in regulating ROS homeostasis, but whether there correlation between NRF2 unclear. Here, we showed increases proliferation migration by inducing upregulation. We further found at both mRNA protein levels. Our data also primarily upregulates increasing promoter activity rather than or stability. Using DNA pull-down/MS analysis, recruit YBX1 upregulate activity. hTERT/YBX1 may localize P2 region of promoter. Taken together, our results demonstrate facilitates upregulating through recruitment transcription activate These provide new theoretical basis for treatment.